10/31/2023 0 Comments Antidote for warfarin overdoseActivation of Mania or Hypomania: Prior to initiating, screen patients for personal or family history of bipolar disorder, mania, or hypomania ( 5.8).Severe Skin Reactions: Severe skin reactions, including erythema multiforme and Stevens-Johnson Syndrome (SJS), can occur Discontinue at the first appearance of blisters, peeling rash, mucosal erosions, or any other sign of hypersensitivity if no other etiology can be identified.Concomitant use of antiplatelet drugs and anticoagulants may increase this risk ( 5.5, 7.4, 8.1) Increased Risk of Bleeding: May increase the risk of bleeding events.If it occurs, discontinue duloxetine ( 5.4) Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also when taken alone.Orthostatic Hypotension, Falls and Syncope: Consider dosage reduction or discontinuation if these events occur ( 5.3).Avoid use in patients with substantial alcohol use or evidence of chronic liver disease ( 5.2) Discontinue duloxetine in patients who develop jaundice or other evidence of clinically significant liver dysfunction and should not be resumed unless another cause can be established. Hepatotoxicity: Hepatic failure, sometimes fatal, has been reported.
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